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Tian, L. et al. Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators.

ManNAc treatment appeared to ameliorate the hyposialylation status of mutant mice, indicated by a lectin histochemistry pattern similar to that of wild-type mice, with improved sialylation of both nephrin and podocalyxin, as well as reduced albuminuria compared with untreated mutant mice.

Specially, de-ATSC has dramatic regenerative ability in spinal cord injured rats and diabetes mice with improved motor function.

Here we show that injection of wild-type (WT) embryonic stem cells (ESCs) into mdx blastocysts produces mice with improved pathology and function.

However, the female PB signatures were less accurate in distinguishing the non-irradiated from 50 cGy irradiated male mice, with improved accuracy in predicting non-irradiated samples from male mice irradiated with higher doses of radiation (200 cGy and 1000 cGy; Figure 2C).

Others also found a positive effect on survival in IL-6 knock-out mice with improved renal function [ 105, 106].

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Although IgM mAbs might already be useful for some specific applications or could be modified by Ig class swapping to obtain IgG mAbs [36], optimized humanized mouse models with improved B cell function are highly desirable.

To obtain humanized mouse models with improved B and T cell homeostasis, alternative strategies not relying on the transplantation of human fetal tissues – which are not necessarily easy to access to, for ethical, legal or practical reasons – will likely be favored in the future.

In comparison with iv/+ mice, iv/iv mice improved dry maze performance more slowly, but little difference was found after the performance reached asymptotic level (Figure 3).

Inhibition of NO production in sarcoglycan mutant mice was associated with improved recovery after carbachol and isoproterenol infusion.

In this study, treating mice with PD1 improved mouse survival and mitigated pathology of influenza-infected mice.

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