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Synovial staining for CD248 was relatively weak within the joints of non-inflamed control mice with few positively staining cells.
However, the similarity is mainly limited to mice, with few overlapping genes detected between ISO-treated mice and the various rat models.
Histology showed little immune cell infiltrate in S. pneumoniae-infected mice, a modest infiltrate during influenza and massive cellular recruitment in coinfected mice, with few unobstructed airspaces (Fig EV2D).
Interestingly, C16, C18, and C20 ceramides showed a trend to increase in hearts of fed MED13cTg versus fed WT mice, with few changes in the other ceramide species in fed or fasted mice (Supplementary Fig S2D).
The inability to mobilize transposons in transgenic mice with few transposons in the concatemer is consistent with our efforts to re-mobilize a single copy insertion in the genome.
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Now a study shows that mice with fewer new neurons can't distinguish a familiar and a new odor--leading some to conclude that these neurons are important for learning and memory.
MYC/Rb double mutant mice showed a significant increase in ploidy compared to MYC mutant mice, with fewer 2n populations and more 8n and 16n populations (Figure 5D).
This microglial reaction was attenuated in TP-10 treated R6/2 mice, with fewer reactive cells evident among the normal quiescent cells (Figure 7C).
LPS (100 μg/kg) induced Fos protein expression in several brain nuclei of control mice, with fewer Fos-positive cells observed in the brains of obese mice.
In complete agreement with previously published work [ 30] while young muscle was robustly repaired at 5 days post injury (5DPI) with new regenerating myofibers, tissue repair was significantly worse in the old mice, with fewer newly formed myofibers and evident fibrosis.
This change in the early dynamics of infection in aged mice, with fewer bacteria present during the first 24 h, correlates with decreased and/or bimodal upregulation of costimulatory molecules by the CD8α+ DC population in aged animals at early time points post-infection (Fig. 4A C), and with decreased CD8 T-cell priming and accumulation (Figs. 1 and 2).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com