Sentence examples for mice will require from inspiring English sources

As homozygous deletion in PKD1 or PKD2 in mice causes embryonic death, examination of touch sensitivity in PKD-deficient mice will require a conditional knockout [55].

The relative contribution of each organ to the increased energy expenditure in HSL null mice will require the generation of mouse lines in which the HSL gene has been inactivated tissue-specifically.

The successful use of split-CreERT2 in living mice will require that tamoxifen reaches the targeted cells in sufficient concentrations to induce split-CreERT2 nuclear translocation by binding to the ERT2-domain.

Since, at present, little is known on the nature of the signals produced by an adult muscle fiber to maintain the stability of the neuromuscular contact, the precise signalling mechanisms elicited by mitochondrial uncoupling and their relative contribution to the pathology of these mice will require further investigations.

A detailed understanding of how hypoactivity manifests in Salm3−/− mice will require further exploration.

This embryonic lethal phenotype means, however, that elucidation of the physiological function of the Zfp36L1 protein in cells and tissues from adult mice will require conditional KO strategies.

"This measurement suggests that uniquely barcoding the roughly 12 billion cells in a mouse will require at least 7 such [self-targeting CRISPR sites] per cell," the authors write.

The mouse will require more assistance than with the oil method.

Before human clinical trials can commence, the mouse model will require significant optimisation, for example increasing the efficiency of new photoreceptors to connect with the damaged retina.

Thus, although a low dose of resveratrol can improve quality of life by retarding aging parameters such as cardiac dysfunction, a nutritional or pharmaceutical strategy to also increase lifespan in mice will likely require blockage of the IGF-1 axis or its targets.

All of these findings would be consistent with TRIM33/PU.1 antagonism being relevant to the phenotype observed in TRIM33-deficient mice, however definitive evidence will require additional genetic experiments in normal B lymphoid cells.