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However, although direct gene delivery strategies exhibited variability in terms of the number of successfully transduced humanized mice, the use of genetically modified fibroblast-containing matrix as an in situ protein bioreactor was highly reproducible, leading to a significant improvement of the overall healing process.
As documented by others, to develop GVHD in NOG mice, the use of toxic liposomes is not necessary [35].
As our results indicate that the mutation HA2 K58→I increases the infectivity of H5 viruses for mice, the use of amantadine in clinics, or especially in farming, could support the appearance of H5 HPAIVs more infectious for mammals [37].
Although our previous study demonstrated the protective capacity of the Hcβtre and Hcβtre-Ad2F immunogens when delivered nasally to mice, the use of a mouse model may not be ideal when evaluating immunogens for nasal delivery to humans.
In mice the use of a histone deacetylase inhibitor delayed significantly the onset of labour [ 23].
Most experiments reported here employed C57BL/6 mice; the use of nude mice is explicitly noted in the text.
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This protocol minimized any suffering for the mice used through use of analgesics where appropriate.
Alternatives to GM mice lie in the use of genetically altered cells and tissues or donated human diseased tissue.
We calculated the BMCL for the B6C3F1 mice using the same methods as for DO mice.
The enzyme is secreted by the mouse's salivary glands, helping the mouse make use of the naturally occurring phosphates in its feed and reducing the level of phosphates in the feces.
And the more the mouse was used the more dust it would pick up off the tabletop, and the more it would skip.
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