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In a more vulnerable system, i.e. in C57Bl/6 normal and knock-out mice abrogation of one cell type makes the mice sensitive to tumour outgrowth.
Enhancing adenosine deaminase activity in podocytes is not sufficient to render mice sensitive to PAN in terms of nephrotic syndrome.
The first one consisted in selecting or generating a genetic background to render mice sensitive to PAN, as attempted in this study.
Cdo –/− mice have a largely sub-threshold defect of Shh signaling in the rostroventral midline that renders these mice sensitive to additional, often silent, insults.
Even indeed, not only were the caspase-7−/− mice sensitive to LPS doses, IL-1 β/IL-18/caspase-7 triple knockout mice were not additively protected in comparison with IL-1 β/IL-18 double knockout mice.
Mowers et al. also treated obese mice with amlexanox, a drug that inhibits these enzymes, and found that this treatment made the mice sensitive to a synthetic catecholamine that triggered the release of energy from fat.
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D'Hulst wanted to improve on the HeroRats concept by creating a genetically modified "supersniffer" mouse, sensitive to the specific odour of the explosives in landmines, TNT.
It was recently shown that tlr4 −/−/tlr2 −/− mice are sensitive to Salmonella infection, but mice deficient in TLR2, TLR4 and TLR9 are less sensitive.
In the present study, we confirmed that BALB/C mice are sensitive to ADR-induced nephropathy, while C57BL/6 mice are resistant to such damage.
Depletion of NK cells before infection with CVB3 rendered resistant strains of mice as sensitive to the development of myocarditis as susceptible strains of mice [ 66].
All FA mouse models show reduced fertility, and cells derived from all mutant mice are sensitive to ICL-inducing agents – the characteristic cellular phenotype of FA.
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