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We utilized existing mice possessing a conditional knock out for the Apc gene and a latent activated Kras allele and crossed them with mice expressing Cre recombinase solely in the large intestine.
We have shown that mice possessing a fibroblast-specific deletion of Rac1 exhibit impaired myofibroblast formation and function, associated with delayed cutaneous tissue repair and resistance to bleomycin-induced fibrosis [26], [27].
Here we investigate the meiotic functions of BAZ1B (WSTF), the only known Tyr142 kinase in somatic cells, using mice possessing a conditional deletion of BAZ1B.
Female Tg2576 transgenic mice possessing a copy of human APP with the Swedish double mutate on (KM670/671NL) were obtained from Taconic and aged to 18 months.
CCN2 is expressed in mesenchymal cells during development, and mice possessing a deleted Ccn2 gene die soon after birth due to an inability to breathe caused by a failure in rib cage ossification, angiogenesis and matrix remodeling [ 6].
Highly virus-induced diabetes-susceptible strains such as SJL and SWR mice possessing a mutated Tyk2 gene, which is associated with reduced expression of Tyk2 gene in pancreatic β-cells, were prone to the development of diabetes caused by the diabetogenic strain of EMC-D virus (Izumi et al., 2015).
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Muc2−/− mice possessing an Apc mutation have significantly increased colorectal Carcinogenesis, perhaps through an interaction between β-catenin and chronic inflammation [146].
Interestingly, late middle-aged (approximately 25-month-old) GHR-KO females have a greater BAT weight:total body weight ratio than their littermate controls (P-value < 0.0001, Fig. S26); this lends some evidence as to how GHR-KO mice, possessing an abnormally high surface area-to-body volume ratio, counteract their physical predilection to hypothermia.
After the cut-and-paste operation, the mice possessed a good working copy of human Factor 9, producing enough to make their blood clot much faster, and well enough to prevent hemophilia, Dr. High and her colleagues report in the journal Nature.
A few years ago, neuroscientist Jeffrey Mogil of McGill University in Montreal, Canada, reported in Science that mice possess a simple kind of empathy called emotional contagion.
Myonuclei from wild-type mice possessed a condensed chromatin layer directly inside the nuclear membrane.
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Justyna Jupowicz-Kozak
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