The in vivo antitumor effect of the paclitaxel (PTX -loaded nanoPTX -loadedas inanoparticlesn Kunming mice harboring a hepatic H22 tumor.
Furthermore, the compound K-rasLSL-G12D/p53LSL-R270H mice developed tumors faster and more robustly than mice harboring a single K-rasLSL-G12D oncogene, as expected.
We designed 19 different allele-specific siRNAs for Trembler J (Tr-J) mice harboring a naturally occurring mutation (Leu16Pro) in Pmp22.
Conditional knockout (STAT3-KO) mice harboring a cardiomyocyte-restricted deletion of STAT3 showed enhanced susceptibility to cardiac injury caused by myocardial ischemia, systemic inflammation, or drug toxicity.
Here, we show that mutant mice harboring a newly described mutation termed Beetlejuice (Bj) in Prickle1 (Pk1), a PCP component, exhibit developmental phenotypes involving cell polarity defects, including skeletal, cochlear and congenital cardiac anomalies.
Transgenic mice harboring a construct in which the LacZ gene is driven by the Six2 promoter fragment revealed LacZ expression at multiple sites which overlap with endogenous Six2 expression.
"Using transgenic mice harboring a chromosomally integrated lacZ reporter gene" "Interestingly, the small intestine, a tissue with a very high cell proliferative activity, was found to undergo the largest age-related increase in mutant frequency among all organs studied, i.e., from 11.0X10^-5 in young mice to 25.6X10^-5 in old mice [primary source].
To discern the in vivo functions of one of these Smads, Smad3, we generated mice harboring a targeted disruption of this gene.
We generated Sox6fl/fl adult mice harboring a widely expressed CaggCreER transgene [36].
As expected, none of the chimeric mice harboring a Prp0/0 genetic background developed a clinical disease, for lack of expression of PrPc protein [1].
Using transgenic mice harboring a chromosomally integrated lacZ reporter gene our laboratory has previously demonstrated an age- and tissue-specific increase in spontaneous mutations in vivo [2,3].
