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Mice that developed HI-antibodies against IAV HK/68 (all mice of group 2 and four of group 6) were protected from weight loss after infection with IAV HK/68, while mice of other groups lost weight until day seven post infection (p.i).
When the study reached week 3, all treated mice showed comparable renal uptake of 99mTc-DMSA, which was in the same range as for the control mice of group A (data not shown).
After successful modeling, mice of group one were injected intravenously with oMWCNTs for 3 days (500 μg/mouse), and the other one were continuing to inject intraperitoneally with L-arginine for 3 days (6 mg/mouse).
Application of high activities of 161Tb-folate (group D, 30 MBq) resulted in a significant increase of creatinine plasma levels (77 ± 17 μM), as compared to control mice of group A (24 ± 5.1 μM (n = 6), <18 μM (n = 3)) at terminal state and the same observation (creatinine level of 107 ± 35 μM) was also made for 177Lu-folate treated mice (group G, 30 MBq).
Tumors from mice of group 1 (G1) were frozen or fixed immediately.
Four mice of group 6 developed detectable HI-antibody responses with a GMT of 48, the other mice of this group did not seroconvert (figure 1A).
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Other than that, the determination of blood urea nitrogen and creatinine plasma levels did not confirm a significant difference of the renal function in mice of groups D and G at any time of the study.
In contrast, mice of groups 4, 5 and especially group 2 had more severe lung pathology characterized by a multifocal to coalescing severe subacute necrotizing bronchopneumonia.
Insignificant alterations of serum total protein were observed in mice of groups 3, 4, and 5.
Anterograde tracing: 4 weeks after surgery, the CST of mice of groups 4 7 was anterogradely traced from the smHL ipsilateral to the treated cortex.
All unlesioned mice of groups 4 and 5 (Pase and ChABC injected, respectively) walked on the grid with ease, showing correct hindpaw placement.
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