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The application of isotope tracers for investigating metabolism in mice is discussed.

In addition, the implication of such findings for studies on genetically modified mice is discussed.

Modelling breast cancer using transgenic mice is discussed in detail in chapter 7 by Dillon and Muller.

The importance of these findings in light of recent evidence for a carcinogenic effect of VDC in mice is discussed.

The existence of factors which induce a loss of negative surface charge on spleen cells of some tumour-grafted mice is discussed.

Additionally, the results of a study in which myeloid hyperplasia was induced following the formation of skin tumors in SENCAR mice is discussed.

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First, as suggested, phenotypes of Slit2 mutant mice were discussed in the third paragraph of Discussion.

Together, our findings in BXD29-Tlr4lps-2J/J BXD29-Tlr4lps-2J/J BXD29-Tlr4lps-2J/Jthe known neuroanatomicend phenotype of other SBH rodent models.

Studies carried out in rats and mice are discussed separately because the tumorigenesis models used in the two species are different.

Three factors that affect prediction between rats and mice are discussed: chemical class, mutagenicity in the Salmonella assay, and the dose level at which a chemical is toxic.

Finally, the impact of this technology to such diverse fields as bacterial pathogenesis, metabolic engineering, and mouse genomics is discussed.

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