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Swiss Albino mice is based on affinity and rapid higher antibody response during the efficacy studies.
Dose evaluation regarding indometacin LD50 50 mg/kg in mice is based on a 14-days mortality response.
Therefore, it does not seem that the increased AP in Alk1 +/+ mice is based on alterations in renal function or structure.
Our results suggest that the cancer resistance in SR/CR mice is based on at least two separate processes: leukocyte migration/infiltration to the site of cancer cells and recognition of common surface properties on cancer cells.
These results support the hypothesis that higher molecular weight aggregates and tangles are neurotoxic and suggest that the therapeutic effect of anle138b in PS19 mice is based on inhibiting the pathological aggregation process.
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Our choice for female mice was based on recent study describing that the estimated new cases of colon cancer in 2009 was predicted to be higher in females compared to males [60].
Age, sex, and genetic strain of mice were based on previous data, in which the time course of fracture healing had been established by both histological and selected candidate gene assessment [8] [11].
Disease activity scores for DSS treated mice were based on the cumulative scores (0 10) from 3 different parameters: Stool consistency (0 = normal, 1 = soft but still formed, 2 = very soft, 3 = diarrhea), presence of blood in stool (0 = negative heamocccult, 1 = positive hemoccult, 2 = blood traces visible in stool, 3 = rectal bleeding) and histological changes (0 4).
RGS5-deficient mice were based on a C57BL/6 background.
Its first useful applications in mice were based on a combination of temporal and spatial regulation [ 47- 49].
Conditions of use (COU) for the mice are based on community standards and are identical to the COU currently covering mice from The Jackson Laboratory.
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