Sentence examples for mice have generated from inspiring English sources

By this time, these mice have generated high titers of B. parapertussis-specific antibodies [24].

Conditional inactivation of lkb1 in a number of tissues in mice have generated tumours in breast, pancreas, prostate, skin and bone.

For example, small RNA-cDNA libraries from the ovaries of 2-wk-old and adult mice have generated a number of miRNAs with potential role in ovarian function [ 24].

The study of PANK2 function is complex, and efforts to generate animal models of disease by knocking out the gene in flies and mice have generated incomplete phenotypes, lacking signs of neurodegeneration and/or of brain iron accumulation (5, 6).

Extensive histopathological studies and investigations on the initiation of atherosclerosis in transgenic mice have generated a quite detailed picture of the development of atherosclerosis in the various stages of disease [ 56– 63].

However, while these studies confirm the general notion that oxidative damage is associated with aging, recent studies in mice have generated conflicting results as few of the genetic manipulations targeting conserved antioxidant genes showed the predicted effects on lifespan (Perez et al., 2009).

However, manipulation of myostatin expression in transgenic and knockout mice has generated conflicting results.

ENU-induced mutations in mice had generated the Svc mouse that is small and has vacuolar cataracts [29] resulting from a missense mutation in the Col4a1 gene that encodes collagen IV [20].

We believe that the modulation of the diet composition in Pank2 knockout mice has generated a useful model system in which to test not only pantethine, but also additional compounds, which could be beneficial for patients.

Like Kras loxP-STOP-loxP-G12D mice, investigators have generated mice in which Kras G12D is regulated by a transcriptional terminator sequence flanked by FRT sites in the endogenous promoter (Kras FRT-STOP-FRT-G12D) (Young et al., 2011).

To enable well-powered studies in mice, we have generated high-density genotypes for ∼175 inbred strains of mice using the Mouse Diversity Array.