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NET formation may also injure the host [21]: our finding that DNase-treated mice have diminished hepatocellular injury after infection is consistent with previous reports in which mice deficient in NET components have decreased hepatocellular inflammation compared to controls in an E. coli-induced sepsis model [55],[55].

Moreover, SR-A deficient mice have diminished clearance of S. aureus and survival following IP infection, and macrophages from SR-A deficient mice exhibit diminished phagocytosis of S. aureus [5].

These mice have diminished reactive astrocytosis.

PDGFβ and PDGFβR knockout mice have diminished pericyte numbers and a lack of pericyte coverage [ 87].

Recent studies have demonstrated that during fasting, SIRT3-/ mice have diminished fatty acid oxidation, develop a fatty liver, have low levels of ATP production, and show a defect in thermogenesis and hypoglycemia during a cold test [ 22].

Second, naïve IL-21R KO mice have diminished serum IgG1 levels and immunization of these mice with T-dependent antigen results in lower antigen-specific IgG1 levels compared to wild-type mice [ 3].

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Microglia from Becn1+/− mice had diminished Beclin 1 protein levels compared to control mice (Figure 6I).

When total β-cell mass was calculated, only Myd88−/− mice had diminished β-cell mass (Figure 1E).

Relative to V394L/V394L mice, 4L C* mice had diminished GCase protein and activity.

Late generation TERC−/− mice had diminished angiogenesis potential compared with wild-type mice [ 128] and suffered from severe left ventricular failure, cardiac structure change and myocyte hypertrophy [ 106].

To directly examine whether necroptosis inhibition is associated with reduced activation of the NLRP3 inflammasome, we tested whether APAP+Nec-1-treated WT mice had diminished Caspase 1 activation and IL-1 β generation.

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