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By contrast, while C57BL/6 mice generated little dose dependent increases in the Th1 cytokine IFN-γ, BALB/c mice generated more robust dose dependent increases in this cytokine (Fig. 3c).

Comparing the higher affinity DO11.10 mice to OT-II mice revealed that DO11.10 mice generated more CD4SP thymocytes as expected for thymocytes that have higher affinity TCRs and thus better able to be selected (expectation of 1 if DO11.10 and OT-II mice have equal ability to generate CD4SP thymocytes, actual ratio, 5.3, Fig. 5a).

MDSCs from tumor-bearing mice generated more soluble IL-6Rα compared to 4T1 cells.

Neutropenic mice generated more prostacyclin in vivo, however vascular tone was not restored using prostaglandin H synthase inhibitors in vitro or in vivo.

Consistently, MEFs gave rise to alkaline phosphatase (AP) positive iPS-like colonies at higher frequency than did TTFs, and TTF from 4 week old mice generated more iPS-like clones than did TTF from 8 month old mice (Fig. 2B).

As shown in Figure 6A, bone marrow cell cultures from c/ebpβ−/− and from L/L mice generated more and larger osteoclasts (containing more nuclei/TRACP-positive cell) compared with WT cells after 6 days of treatment with M-CSF and RANK-L.

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In a report in the Friday issue of Cell, he described the two drugs that successfully activate the muscle-remodeling system in mice, generating more high-endurance Type 1 fiber.

Further, Cdc42−/− mice generate more LCMV-specific memory cells, compared to WT mice.

Kamimura et. al. [ 22] suggests that Bcl11b may be haploinsufficient for suppression of tumors, since Bcl11b+/- p53+/- mice generates more spontaneous tumors than do Bcl11b+/+ p53+/- mice.

Delayed cell surface internalization may actually provide an advantage by prolonging antigen presentation to augment CTL priming, a notion consistent with our previous observation that Δ7 mice consistently generated more vigorous antiviral CTL responses compared to KbWT mice [21].

Although the first transgenic mice were generated more than 15 years ago, there are no reports of successful monitoring of environmental pollution, especially air pollution, using transgenic mice, conceivably because of the following reasons.

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