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In these mice, development of cirrhosis was blocked, presumably because the telomerase rescued certain short-telomere cells from crisis, enabling them to regenerate the liver.
In fat-fed Apoe−/− mice, development of atheroma is not driven directly by the rise in blood pressure [37].
Although previously, it was difficult to detect metastasis in living mice, development of luciferase and the bioluminescent technology has now enabled the detection of cancer cells in distant organs.
This further demonstrates that in the ST3Gal-I/PyMT, mice development of tumors is initiated significantly earlier than mice on the same background but without the ST3Gal-I transgene.
In JunBΔep mice, development of an SLE-like phenotype (including skin lesions and immune complex glomerulonephritis) was linked to increased epidermal IL-6 secretion that arose from the specific loss of epidermal JunB.
However, administration of NAC attenuated the development of the most prominent age-related phenotype of Bmal1-/ mice, development of cataracts, and even most importantly, significantly extended the average and maximal lifespan of Bmal1-/ mice.
Similar(52)
In mouse, development of numerous traits of senescence were decelerated or stopped (in certain cases, even reversed) by very small amounts of SkQ1 [ 16, 26].
It is highly expressed in the mesenchyme and is critical for mouse development of heart, skeletal muscle, and vein (Pereira et al, 1999; Lee et al, 2004; You et al, 2005; Lee et al, 2012).
Despite the severe defect of pro-B cells in Egr-2 cTg mice, the development of B cells in Egr-2 cKO mice is normal.
Histopathology of moribund mice indicated development of bubonic plague as lymph nodes taken from subcutaneously challenged mice on day 4 post-infection showed severe hemorrhage and necrosis similar to wild type (Figure 6).
We found that, in contrast to wild type mice, the development of pulmonary emphysema was significantly inhibited in caveolin-1 null mice [ 33].
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