Exact(1)
Ten days after injection (a time-point by which 95 100% of mice develop established lung metastases) mice were allocated to two treatment groups as per above.
Similar(7)
Subsequent genetic studies revealed that Beclin 1 null mice die early in embryogenesis and Beclin 1 heterozygous mice develop spontaneous tumors, establishing Beclin 1 as a haplo-insufficient tumor suppressor.
In this model, the mice develop a fluctuating parasitemia, and the parasites become established within the CNS between 14 and 21 days post-infection.
Fifty-sixty percent of mice develop arthritis within 15-30 days post collagen injection and the mechanism is established[ 14].
Importantly, ASPP2 heterozygosity is sufficient to predispose mice to develop tumours, establishing ASPP2's tumour-suppressive function.
Twenty-six mice developed lesions in the lungs, eight of them were selected to establish our imaging studies due to detectable metastasis progression, and four mice did not develop detectable tumors.
After the two stable cell lines were established, they were injected into the footpads of inbred Chinese 615 mice to ensure that all the mice developed a "primary tumor".
The mice developed F.F.I.
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