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Experiments in mice have established that specific nerve cells in the retina, which were thought to be involved in purely sub-conscious processes, have an important role in visual perception.
The present study indicated that the H9N2 viruses with enhanced pathogenicity to mice have established a stable sublineage in chickens in northern China.
Several studies using genetically engineered mice have established a link between autophagy and cancer development (51– 51).
Studies on DCN knockout mice have established that a lack of DCN is permissive for tumor development and it is regarded as a tumor suppressor gene.
The DEN-initiation and PB promotion studies in CAR knockout mice have established that CAR is necessary for liver tumor promotion by PB (39).
Experiments in mice have established a major role for the transcription factor Otx2 in the development of the midbrain DA progenitors.
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This is consistent with the unaffected carrier displaying BM defects despite substantial collagen deposition, since studies in heterozygous Col4a1/ Col4a2 knockout mice have establish that reduced collagen levels per se do not result in BM defects (27).
The broad use of transgenic and gene-targeted mice has established bone marrow-derived macrophages (BMDM) as important mammalian host cells for investigation of the macrophages biology.
At this time, the wt mice had established normal spleen morphology with little or no signs of cell death.
A pioneering study in mice has established that silencing of miRNA levels is feasible in vivo by injection of modified antisense oligonucleotides called 'antagomirs ' (Krutzfeldt et al, 2005).
Treatment was initiated when sufficient number of mice had established tumours to allow randomisation into treatment groups: day 17 for D425Med, day 26 for D384Med and day 32 for D283Med.
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