Sentence examples for mice carrying two from inspiring English sources

Homozygous mice carrying two missense alleles of Dnmt3b show many ICF-like characteristics, including hypomethylation of heterochromatin repeat DNA.

We have studied mice carrying two null alleles for SirT1, the mammalian orthologue of sir2, and found that these animals inefficiently utilize ingested food.

To clarify this issue, we generated Mib1 conditional knockout mice carrying two loxP sites between exons 1 and 2 and between exons 3 and 4 (Figure S1).

More commonly, there was no second peak, although subsequent phenotyping and histological analysis [17] showed that the proportion of mice carrying two copies of the transgene was 0.25, as expected.

We analyzed Itk−/− mice crossed to mice carrying two TCRs reactive against ovalbumin, the low affinity MHC class II-restricted transgenic TCR (OT-II) and the higher affinity (50 fold) MHC class II-restricted transgenic TCR (DO11.10).

Unlike knockout of TRPV4, an ion channel expressed by cochlear hair cells, spiral ganglion neurons, and stria vascularis marginal cells [27], which displays increased susceptibility to acoustic injury [25], mice carrying two inactive Trpml3 alleles did not show increased acoustic vulnerability.

The researchers used the technique to clone mice carrying one of three mutations that kick-start cancer at the embryonic stage.

In particular, mice carrying three functional alleles of the p53 gene (p53-super) have a 50% increase in p53 gene dosage relative to wild-type mice (p53-wt), and this increase in p53 activity translates into a significant delay in the latency of 3MC-fibrosarcomas [43].

Northern blot analyses of RNA derived from various tissues obtained from mice carrying one Mdm2puro allele and one null Mdm2 allele (Mdm2Δ7-12 [34] or Mdm2Δ7-9 [38]; collectively referred to as Mdm2null) revealed that expression of full-length Mdm2 mRNA was significantly reduced in all tissues examined including spleen, thymus, kidney, liver, and brain [38].

Brain sparing was similarly apparent in newborn mice carrying three copies of the transgene (Phlda2+/+BACx3) examined on the 129 genetic background (Fig. 3B).

To evaluate the persistence of inhibition of melanoma tumour growth after treatment with MLN8054, treatment was suspended in 14 tumour-bearing mice carrying three different patient tumours and tumour growth was monitored.