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Taken together, the results indicate that only the CD8+ DC subset from infected mice can generate significant protective immunity in vivo.

Finding that knock-in mutant mice can generate giant osteoclasts is an important result, since this cellular phenotype resembles the human Pagetic osteoclast phenotype.

Implantation of embryonic skin precursors (PESPs) of different gestational ages in nude mice can generate the integrity skin, including epidermis, dermis and skin appendages, such as sweat gland, hair follicle, sebaceous gland, etc.PESPs of embryonic day 42 possess the maximal growth potential, while, the safe window time of PESPs transplantation for prevention of teratoma risk is E56 or later.

Recently, Cilloniz et al. found that Mx1+/+ mice can generate a protective antiviral response by controlling the expression of key modulator molecules associated with influenza virus lethality [ 98].

This is supported by the findings of Tang and colleagues [ 26], who demonstrated that inoculation of HRG-transfected MCF-7 cells into the mammary fat pads of ovariectomised, athymic nude mice can generate oestrogen-independent and anti-oestrogen-resistant tumours.

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Therefore, the sacrifice of a single mouse can generate several BM-containing cryovials (usually from 4 to 10).

Taken together, in view of our recent demonstration that CJ83193 can serve as an effective vaccine in preventing HSV-1 infection in mice, one can generate a CJ83193-like HSV-2 recombinant virus that could potentially function as a new therapeutic class of recombinant viral vaccine against HSV-2 infection.

Gluten causes coeliac disease in genetically susceptible people and causes gut dysfunction in mice and can generate IBS symptoms in the absence of coeliac disease.

When the p53 FRT alleles are combined with Kras FRT-STOP-FRT-G12D mice, Flp can generate primary sarcomas, lung cancer and pancreatic cancer (Lee et al., 2012; Moding et al., 2015, 2014; Schönhuber et al., 2014).

To evaluate whether cryopreserved newborn mouse ovaries can generate sufficient numbers of parthenogenetic mouse embryonic stem (pmES) cells for autologous stem cell therapy.

Together, these data demonstrate that the binary transgenic mouse (NVF) can generate increased levels of endogenous ROS in ECs upon withdrawal of tetracycline.

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