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The effects of deletion of neurons in the vlPAG on sleep in mice are unknown.

The reasons for the increase in soleus muscle weight in Akt2ko mice are unknown.

However, the mechanism(s) through which DC expressing IL-4 function to prevent autoimmune diabetes and whether this treatment can reverse disease in pre-diabetic NOD mice are unknown.

The reasons for the apparent rewarding effects of CRF in CRF2R knockout mice are unknown, but prior studies have shown that CRF1-R activation can increase dopamine cell firing and dopamine release in brain structures associated with reward, including the ventral tegmental area and nucleus accumbens [5], [35].

The consequences of Tbg overexpression in mice are unknown.

The mechanism(s) and significance of this persistent component of gender difference in mice are unknown and need further study.

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However, the effect of ginsenoside Rg1 on lipopolysaccharide (LPS) -induced acute lung injury (ALI) in mice was unknown.

Morin hydrate, a flavonoid from Mulberry has demonstrated antioxidant and neuroprotective activities but its effect in sleep disturbed mice is unknown.

The exact mechanism underlying increased neurogenesis in the aging dentate gyrus of Psen cDKO mice is unknown.

Whether such rapid bone depletion during early gestation occurs in species other than mice is unknown and requires investigation.

Since the size of marker alleles in wild-derived mice was unknown, hundreds of markers, which were selected on the basis of allelic information on the CAST/Ei and C57BL/6J strains from the Mouse Genome Database on all chromosomes (Chrs), were tested using the parents and F1 mice.

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