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Despite of these complexities, mice are essential discovery tools in the post GWAS era.

Genetically engineered mice are essential tools in both mechanistic studies and drug development in colon cancer research.

Gene-modified (GM) mice are essential resources for studying gene function, developmental processes, and human diseases [ 1, 2].

At the practical level, high rates of EcoHIV/NDK sexual transmission in mice are essential for statistically reliable evaluation of interventions to block this transmission (Fig. 3).

We strongly believe that KO comparisons to WT littermate/cagemate mice are essential to control for environmental variables and possible genetic drift of the colony.

Because the immune system plays an important role in the development and progression of cancer, models that can be used in immunocompetent mice are essential for analysis of cancer progression and evaluation of therapeutics for cancer treatment.

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But the report argues that the use of mice is essential in some cases and should not be banned.

It has been shown that an early control of infection by natural killer (NK) cells in resistant mice is essential to avoid mousepox lethality [6].

Animal experiments have revealed that the predominantly neutrophilic inflammation in the airways of infected mice is essential for the eradication of A. baumannii from the lungs [22] [24].

Establishing animal models of psychiatric disorders using genetically engineered mice is essential for investigating the pathogenesis/pathophysiology and treatment of these disorders [1], [2], [3].

Using analysis of gene-targeted mice, we have also shown that neither the third component of complement (utilizing C3−/− mice) nor the free radical mediator nitric oxide produced by iNOS (using iNOS−/− mice) is essential for clearance of Mp (Figure S8).

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