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Although the details of timed gene expression are likely to differ between mice and humans — mice are active at night rather than during the day — it could be that the majority of human genes fall into this category.

Others were given access to running wheels only in the early portion of their waking time (mice are active at night) or in the later stages, the equivalent of the afternoon for us.

It is intriguing that hypothalamic AMPK activity has a diurnal oscillation that peaks during the dark period when mice are active and eating.

In the social interaction test in the home cage, time spent separated is usually increased when mice are active and decreased when mice are sleeping.

An increase in respiratory exchange ratio during the dark phase, the period in which the mice are active, indicates a switch from fat to carbohydrate oxidation.

In contrast to the old and more sedentary animals, young mice are active and the old partner literally has to tag along.

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Similar to our control experiments (Fig. 1), group mean activity profiles from Bmal1+/+ mice showed that mice were active during the time of prior food availability on the first (601±1005) and second (4104±1941) days of food deprivation (Fig. 2B; FAA from individual mice shown in Fig. 3B).

The LysM gene in mice is active mostly in monocyte/macrophages and neutrophils [38], [39].

The CD2 promoter used to create Egr-2 cKO and cTg mice is active in both T and B lymphocytes [17].

In contrast, by gradually reducing food availability and by placing food pellets on the bottom of the cage, we found that most Bmal1−/− mice were active and healthy during restricted feeding [39].

These data indicate that a robust population of deer mice was active at Curry Village in summer 2012.

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