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Much of DC research so far has been carried out in mice and increasing efforts are now being devoted to translating the findings into humans and other species.

These results suggest that CRF receptor agonist administration is capable of producing a global profile of negative energy balance by reducing food intake in mice and increasing energy expenditure in rats.

Serum GLuc levels in blood from mice bearing tumors injected with rQ-M38G was higher than GLuc levels in control uninfected mice, and increasing GLuc over time traced a profile similar to viral copy number in tumors.

While we did not test scopolamine- or amphetamine-induced locomotion, our ultrasound vocalization studies showed similar effects to those seen by Laviola et al. (2006) with CPO treatment decreasing ultrasound vocalization in WT mice and increasing it in Rl +/− male mice.

Our recent studies in decorin-null mice and increasing decorin expression in human colon cancer cells in vitro have demonstrated an interaction between decorin and E-cadherin, which may underlie another mechanism of the antimigratory and antimetastatic actions of decorin in colorectal carcinoma [5], [11], [17], [18].

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Access to ethanol altered daily activity patterns in both B6 and D2 mice, and increased activity levels in D2 mice, but had no effects on other circadian parameters.

But in other studies, researchers have injected humans with the same solution they gave the mice and increased vitamin C in the blood to more than 10 millimoles.

If our hypothesis is true, we expect to obtain epileptogenesis in adult mice without DREADD manipulations, either abolition or strong reduction of epileptogenesis in hM3D(Gq) mice, and increased epileptogenesis symptoms in hM4D(Gi) mice.

Gel formation significantly increased the activity of immunostimulatory CpG DNA, retarded the clearance after intradermal injection into mice, and increased the immune responses to ovalbumin (OVA) incorporated into the hydrogel as a model antigen.

Osteoblast number was decreased in Cthrc1-null mice, and increased in Cthrc1 transgenic mice, respectively, while osteoclast number had no change in both mutant mice.

Expression levels of osteoblast specific genes, ALP, Col1a1, and Osteocalcin, in primary osteoblasts were decreased in Cthrc1-null mice and increased in Cthrc1 transgenic mice, respectively.

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