We confirm similar changes in a Sod2 knockout mouse model and augmented nitrotyrosination of presenilin in the brains of individuals affected with sporadic AD, adding clinical value to the mechanistic association depicted in this work.
Thus, the amplified sensitivity of Hif-1α mutant mice to PTH and augmented bone formation response appear to be due to an increase in the functional activity of individual osteoblasts.
This deletion diminished Notch pathway activity and increased goblet cell numbers in the small intestine of mice and complementarily augmented goblet cell differentiation in cultured enterocytes (Sodhi et al, 2012).
Deletion of miR-223 resulted in increased susceptibility to TB infection in mice and significantly augmented CXCL2 production, but upon neutralization of CXCL2, the severity of TB infection could be slightly reversed [ 38].
We therefore analysed BAL fluid from bleomycin-challenged mice and observed augmented cytokine accumulation, in particular of IL-1, IL-6, IL-13, and GCSF, in gp130 757F mice when compared to gp130 wt, gp130 757F ; Stat3 +/−, or gp130 ΔStat mice (Supporting Information Fig S4A and B).
The de novo biosynthesis of cholesterol in the liver, as measured with the amount of [1-C]-acetate incorporated into sterols in liver, was markedly increased by 1.49-fold in DKO mice as compared with apoE−/− mice, and this augmented cholesterol synthesis was completely rectified by replenishment with rmFGF21 but not adiponectin.
Current models of jaw development and evolution have been built on molecular and cellular evidence gathered mostly in amniotes such as mice, chicks and humans, and augmented by a much smaller body of work on the zebrafish.
In this study blood flow regulation in the pathogenesis of muscular dystrophy was evaluated using in vivo microscopic assays: we examined how blood flow responds to muscle contraction in mdx and control mice, whether NO/H2O2 production in muscles is attenuated in mdx mice, and whether augmenting the nitric oxide pathway can prevent functional ischemia and the myofiber damage in mdx mice.
Previous reports have also explored the relationship between MCH neurons and reward: both MCH knockout and MCH ablated mice show augmented locomotor responses to psychostimulant drugs (Pissios et al., 2008; Whiddon and Palmiter, 2013).
Circumstantial evidence from this and previous studies suggest the potential for TASK-3 to be a novel antidepressant therapeutic target; TASK-3 knock-out mice display augmented circadian amplitude and exhibit sleep architecture characterized by suppressed REM activity.
