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In the case of CD14 deficient mice, an additional role for CD14 in controlling p38 MAPK and negative regulators of inflammation such as suppressors of cytokine signaling (SOCS) have been suggested to mediate inflammation through tolerance [66].

Parabiosis provides parabiotic AD mice an additional set of peripheral tissues and organs from wild-type mice.

In the Vezt fl/fl:PrestinCre mice, an additional product of 860 bp lacking exon 5 is also detected.

For the young mice, an additional time point with 2 hours of ischemia and no reperfusion was also examined.

In these mice, an additional challenge with a subnephritogenic dose of heterologous anti-GBM anti-bodies caused glomerular MPO deposition and triggered the development of severe crescentic glomerulonephritis.

Following the testing of these mice an additional cohort was tested, four months older at the time of testing than the first.

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Compared to APP23 mice, deltaE9 mice harbor an additional transgene of a familial AD mutation in PS1 with a deletion of exon 9, accelerating the cleavage of APP and thereby Aβ formation.

Therefore, unlike Sod1 −/− mice, Sod1 D83G/D83G mice have an additional toxic gain of function that causes the degeneration of motor neuron cell bodies.

Each of the 24 infected mice, plus an additional 8 uninfected control mice (age- and sex-matched) were anaesthetized (1.7 parts Dormitor, 1.3 parts Vetelar in 7 parts PBS given at 4 μL/g) and each mouse was exposed to a single experimental cage of mosquitoes (see below).

This HTS high BMD phenotype could not be confirmed in follow-up DEXA or microCT scans of bones (N=10 for both male and female mice) from an additional cohort of KO mice examined at 18 weeks of age (data not shown).

Thus, the transgenic mice acquired an additional peripheral system from wild-type mice.

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