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For example, when kidneys that do not produce interferon γ are transplanted into wild-type mice, an increased early graft necrosis is observed that can be treated with interferon γ.
As expected, we observed in G93A mice an increased NF-κB activation, that is prevented in double transgenic mice (figure 4A and 4B).
During DCB6AdhPrP vaccination of B6 mice, an increased presentation of murine and human surface PrP coexpressed on the same DC, together with exogenous help directed against adenoviral proteins (attested by the presence of antibodies against the hexon and fiber Ad proteins in the sera), may have stimulated antibody production to self-PrP.
In mice, an increased endosteal bone formation has been found in long-term high dose studies of PGE1 analogues (misoprostol) [ 10].
Although many of the phenotypes are shared between the mice, an increased copy of APP is not sufficient to recapitulate all of the AD-related phenotypes of Down syndrome mouse models.
In mice, an increased incidence of bronchioloalveolar adenoma was observed in females at the highest concentration tested (30 ppm) (Abdo et al. 1992), and in rats, the nasal olfactory epithelium was a prominent target after 105 weeks of exposure (Abdo et al. 2001).
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In 3-week-old K5-β1 mice an increasing number of β1 integrin-positive keratinocytes was observed in lacZ-positive areas.
The vessels of female mice had an increased breadth (P=0.018) compared with male mice.
In conjunction, db/db mice had an increased α-cell area compared with non-diabetic mice and α-cell area increased over time (Figure 1B).
Mice lacking one copy of p53 (p53+/− mice) have an increased cancer incidence and a shorter lifespan.
In this setting, Cytip-deficient mice showed an increased ear-swelling reaction after 24 h compared with WT mice.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com