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Current limitations in computational design methodology have led to the adoption of high-throughput screening and affinity maturation techniques to diagnose modeling inaccuracies and generate high activity binders.
To date, advances in methodology have led to the identification of 587 human miRNAs (Sanger updated database [3]), and it is estimated that over 30% of human genes are targeted by these miRNAs [4].
Tumor perfusion is one of the earliest physiological properties to be measured, and advances in methodology have led to increasingly quantitative approaches.
Tumor perfusion is one of the earliest physiologic properties to be measured by molecular imaging, and advances in methodology have led to increasingly quantitative approaches.
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The use of this methodology has led to important findings concerning visual consciousness, which are briefly discussed.
Moreover, peptide library methodology has led to the discovery of IL‐5 receptor α antagonists that mimic key elements in IL‐5 receptor recognition.
Inevitably, such a powerful methodology has led to significant progress in many areas of cancer biology, i.e., the crosstalk of biological signaling and the identification and validation of cancer therapeutic targets (Moffat and Sabatini, 2006; Iorns et al., 2007).
Over the last decade, advances in computational technology combined with contemporary methodologies have led to a vast array of new descriptors [2].
These efforts, deploying appropriate, contextual and emergent synthetic methodologies have led to the total synthesis of numerous epoxyquinone natural products spread over the entire structural landscape, with the added value of generating new chemical diversity space around their scaffold.
Changes in haemodynamic function during 'normal' pregnancy have been relatively well characterised although differences in methodologies have led to some inconsistencies between reported findings.
A number of prior educational interventions have been developed and evaluated for this purpose, but inconsistency of findings, reporting standards, and methodologies have led the majority of reviewers to conclude that the evidence for the efficacy of these programmes remains inconclusive.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com