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In addition, we employed methodological features to account for potential limitations linked to selection of controls.
The study has been designed with attention to key methodological features to minimise bias including randomisation, concealed allocation and intention-to-treat analysis.
100 102 The ultimate decision regarding which methodological features to evaluate requires consideration of the strength of the empiric data, theoretical rationale, and the unique circumstances of the included studies.
Researchers also need to better report their studies in terms of describing the intervention (to allow replication), the study methodological features (to allow judgement of validity), and the numerical and statistical results (to allow meta-analyzing the results across studies).
If substantial heterogeneity is found to be present from the analyses detailed above, then reasons for such heterogeneity can be explored by relating study level co-variates (e.g., population, test, reference standard or methodological features) to an accuracy measure, using meta-regression techniques.
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In addition to appraising the quality of randomised trials, we also assessed methodological features specific to weaning trials that might influence estimates of treatment effect.
This study is designed to include key methodological features in order to minimize bias.
The following methodological features most relevant to the control of bias were assessed: adequate sequence generation, allocation concealment, blinding, selective outcome reporting, and other sources of bias.
As part of this review we have created a publicly accessible online database of these trials including key methodological features and links to the original reports [ 17].
We analysed separately the effect of supplemental vitamin D and active forms of vitamin D, and evaluated both dose and 25(OH D concentrations achieved for supplemental vitamin D. We examined the following methodological features most relevant to the control of bias: randomisation; masking of treatment allocation; blinding; adherence; and withdrawals.
Psychometric studies of multi-item questionnaires often see a need to isolate components of response tendency that are due to methodological features e.g. design or wording of items [ 15, 16].
Related(16)
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