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One methodological difference is the use of a voxel-based analysis of the anisotropy data, while this study used a region-of-interest approach.
A major methodological difference is the use of human cardiac tropomyosin [ 7] or tropomyosin prepared from rabbit skeletal muscle [ 23].
The most important methodological difference is in the null model used to assess whether a sequence pattern is anomalously represented in a given genome.
A second methodological difference is that in those studies a diet cola sweetened with both sucralose and acesulfame potassium (19, 20) was used, so it is unclear whether the enhanced glucose-stimulated GLP-1 response was mediated by acesulfame potassium, a synergistic effect of both sweeteners, or other ingredients contained in the carbonated drinks (20).
Methodological difference is that our research focused on local and complete conservation of nucleotides instead of the dS in the entire region of a gene and that we investigated conservation among the six mammalian species instead of a pair-wise comparison.
With respect to the study by Dudley et al. [27], the methodological difference is that here the authors used a partial SDE composed only of genes with significant differential expression in skeletal muscle atrophy, rather than using a genome-wide SDE.
Similar(54)
A final methodological difference was our use of self-collected nasal swabs and laboratory confirmation of URTI.
Whether these disparate results are due to species or methodological differences is unclear at this point.
Other histopathology studies [ 23– 28], however, have failed to confirm these findings and suggest that methodological differences were responsible for the contradictory results, due to a different postmortem delay in axon count or difficulties in obtaining well-preserved myelinated axons.
So the methodological differences are showing up in a big way this year.
Methodological differences are important in influencing the results of epidemiological studies in headache [7].
Related(20)
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Justyna Jupowicz-Kozak
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