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Another important methodological issue is the availability of reliable techniques for CNMs detection in plant tissues.
A methodological issue is to describe the evidence that would be needed to decide whether a particular interpretation is a sense or a conventional conversational implicature.
This methodological issue is present also in traditional studies that attempt to corroborate their results with papers from different cities or countries [36].
Another important methodological issue is that of hindsight-bias [ 35].
Another important methodological issue is the study-to-study placement of the voxel.
Another important methodological issue is related to the design of an adequate control group.
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In particular differences among human operator models, the allocation of responsibilities in design concepts and methodological issue are elaborated.
A third methodological issue was the oestrogen component in the levonorgestrel products used as reference.
However, thermodilution and echocardiography have both been validated and this methodological issue was considered as acceptable in a previous report [ 18].
The main methodological issue was that only very few studies attempted to blind or mask the intervention conditions to either patients or researchers.
The main feature of this type of document, apart from some methodological issues, is the specificity of topics, being mainly monospecialistic.
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