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Additional file 1: Appendix 1. Methodological comparison of IPD meta-analysis and previous study-level analysis of agreement between MRI and pathologic tumor measurements post-NAC.
Indeed, a methodological comparison of six flow cytometric approaches for EPC quantification using CD34 and VEGFR2 markers has demonstrated only poor to moderate agreement between methods [ 10].
In terms of the second study objective, the methodological comparison of Cochrane vs. non Cochrane study designs (see Figure 3) also support the finding that simple pre-post study designs tend to overestimate CPW effects reported.
The third major implication of our findings lies within our methodological comparison of using recognition vs recall questions to probe for awareness and/or detailed knowledge of the TSS.
In Figure 3 we provide the detailed results of the methodological comparison of the 14 included primary studies which utilised Cochrane EPOC study design quality criteria [ 4] and reporting on LOS [ 10- 23] vs. 14 randomly selected pre-post studies excluded from the review and reporting on LOS as a primary outcome [ 24- 37].
In this regard, our methodological comparison of imputed values against artificially created missing values does not reflect applied imputation scenarios, where a researcher never really knows how well the imputed values represent what data values would have been had they been present.
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SVM has proven to be a robust and versatile approach for clinical prediction, as demonstrated by its consistently high performance in head-to-head methodological comparisons of diverse machine learning methods performed with fMRI data [ 29] and other high-dimensional clinical datasets such as proteomics [ 30] and genomics [ 31].
The low number of primary CPW evaluations included in the review which reported on patient outcomes prevented further testing of the robustness of this methodological comparison.
The results of this methodological comparison study found differing results depending on the type of covariate adjustment method used.
In this paper, the focus is placed on a methodological comparison between two different implementations of the lowest cost route for this kind of system.
Considering the lack of direct methodological comparisons the main aim of this study was to address the comparability of the same paradigm investigated with differing methodologies, namely presenting images on a touchscreen as compared to using solid objects.
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