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The advantage of the approach is its flexibility since it allows to users and administrators to intervene in the system to choose the method of candidate queries recommendations and the ranking queries criteria.
The 'strength' of each candidate compound derived from checking for robustness against perturbation offers a viable unbiased method of candidate selection for further experimentation.
One could argue that, by adopting Sanger method of candidate gene sequencing, BBS2 mutations would have been identified successfully in this case.
Here we employ a previously described method of candidate gene prioritization based mainly on gene annotation, in accompaniment with a technique based on the evaluation of pertinent sequence motifs or signatures, in an attempt to refine the gene prioritization approach.
MRM-MS is quickly becoming the preferred method of candidate biomarker verification because of the discriminating power of mass analyzers to accurately measure and quantify multiple specific proteins within a single sample set.
In this paper, a previously described method of candidate gene selection based primarily on gene annotation [ 25] is complemented by the evaluation of pertinent DNA sequence motifs or signatures to refine the gene selection approach [ 24].
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To some rank-and-file party members, the defeat reflected inexcusable and selfish blunders by Mr. Lee and his failure to democratize the party's own methods of candidate selection.
Because logical candidates have led to few successes in PCOS genetics, novel methods of candidate gene selection are needed.
Using the benchmarking dataset, we compared both Wv and HRC predictions with other known methods of candidate gene prioritization (Table 2).
Comparisons of the different methods of candidate reference gene selection tend to identify the best and the worst reference genes consistently [ 24- 26] when evaluating reference genes whose functions are well defined.
In the present study, to provide a partial solution, we used a hybrid method consisting of candidate gene and genome-wide approaches.
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