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Exact(5)
The metal selectivity of chelators is important because of the risk of depletion of the patient's stores of essential metals.
The metal selectivity of newly identified CDF transporters can be inferred by their position in one of these groups.
Together, our data reveal an evolutionarily conserved mechanism underlying the metal selectivity of EcfS proteins, and provide insights into the ion-translocation process mediated by ECF transporters.
Moreover site directed mutagenesis analyses on other regions potentially involved in substrate specificity and in transporters belonging to the different CDF groups will be useful in finding the molecular determinants of metal selectivity of the CDF family.
The role in metal selectivity of the group-conserved residue D (for Mn-specific CDF transporters) or H (for Zn- and Fe/Zn-CDF transporters) embedded in TMD V is also discussed.
Similar(55)
The promising performances of Ru/CeO2/YSZ were associated to the combination of the positive action of the metal selectivity to syn-gas and of CeO2 in metal dispersion stabilization and coke deactivation prevention.
The authors conclude that a high degree of metal selectivity is conferred by the inherent properties of the proteins.
Many of our data support the notion of metal selectivity.
The mechanism of metal selectivity might be guaranteed by the coordination chemistry in the chemical context of the immediate binding site neighbourhood.
In order to identify an ideal iron chelator for clinical use, a range of specifications must be considered such as metal selectivity and affinity, kinetic stability of the complex, bioavailability and toxicity.
In particular the role of the group-conserved aspartate/histidine residue in metal selectivity has to be verified by complementation tests in other metal-specific sensitive strains.
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