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Figure 1 summarizes the biochemical pathways that are included in the single-cell model: cell metabolism is driven by oxygen, glucose and glutamine, and transforms these substances into energy molecules, molecular building blocks and waste products, following the well-known biochemical reaction chains [24].
It is generally considered that modulation of beta cell KATP activity by glucose metabolism is driven by changes in the ATP/ADP ratio.
Authors' response: (i) Every stage of RNA metabolism is driven by binding of RNA binding proteins (RBPs) through RNA binding domains.
The organism specific recognition of protein-RNA complexes may be attributed with the following perspectives: (i) every stage of RNA metabolism is driven by binding of RNA binding proteins (RBPs) through RNA binding domains.
For instance, the HOT-ALOHA, Guerrero Negro, and YNP datasets all include metagenomes dominated by cyanobacteria whose metabolism is driven by oxygenic photosynthesis, yet clustering of these photosynthetic communities by inorganic factors suggests they have evolved on trajectories optimizing their genomes for conditions specific to each of these environments.
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SIMPER analysis indicates that 30% of the dissimilarity was contributed by changes in RNA and protein metabolism and cellular regulation and signaling (Table S9); interestingly, protein metabolism was driven by a night-time upregulation in universal GTPases suggesting a rapid shift in ribosomal activity at night.
Notably, YqhD is NADPH-dependent [ 48] as compared to the NADH-dependent GldA, thus, YqhD is coupled to anabolic metabolism, which is driven by NADPH.
The extent to which the phylogenetic signal provided by the metabolism genes is driven by HGT requires more detailed analysis of additional taxa as well as an evaluation of syntenic relationships among genes.
The shift of energy metabolism to aerobic glycolysis is driven both by environmental growth conditions and by oncogenic mutations of protoncogenes and tumor-suppressor genes.
FASN gene expression is activated downstream of the PI3K AKT mTOR signal transduction pathway in response to cell metabolism and growth signals, and is driven by SREBP-1, ZBTB7A, and p53 family transcription factors (Van De Sande et al., 2005, Choi et al., 2008).
This likely suggests that the lifespan extension is driven partly by βHB metabolism-independent effects and partly by metabolism-dependent effects.
Related(20)
distribution is driven
policy is driven
uptake is driven
absorption is driven
intake is driven
child is driven
adsorption is driven
equilibrium is driven
plants is driven
policies is driven
metabolism is limited
metabolism is required
metabolism is divided
metabolism is regulated
metabolism is impaired
metabolism is elevated
metabolism is diminished
metabolism is summarized
metabolism is suggested
metabolism is supported
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com