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There are many different schemes that can be proposed for the emergence and evolution of metabolic pathways, depending on the available prebiotic compounds and the available enzymes previously evolved.
C. cellulovorans is known to change production of carbohydrate-related enzymes secreted into media from exoproteome analyses (Esaka et al. 2015; Matsui et al. 2013) and alternation of production of different metabolic pathways depending on which substrates are available in culture is also predicted.
Therefore we investigated if reducing DO2spl differentially affects metabolic pathways depending on the periportal or perivenous localization.
It is known that mammalian spermatozoa solve their energy requirements by switching between different metabolic pathways depending on oxygen availability and the composition of metabolic substrates in their environment.
The genome sequence of L. plantarum 80 contained all genes encoding the enzymes involved in the homo- and heterolactic fermentation pathways (Fig. 2; Additional file 3) as well as various genes encoding carbohydrate uptake systems, enabling this strain to switch between both metabolic pathways, depending on the energy source available.
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Coordination and quantitative adjustment of metabolic pathways depends on induction or repression of transcription of a small number of transcription factors and their coactivators [17], of which PGC-1α plays an overarching regulatory role [19].
Optimization of engineered metabolic pathways depends on our ability to measure the production of intermediates efficiently.
Synthesis of specific transporters and enzymes of particular metabolic pathways depends on specificity for a nitrogen substrate present in the environment, and nitrogen catabolite de-repression.
They found that the presence of different metabolic pathways depended on the pH range adopted and that the production of organic acids increased at pH values between 5.5 and 6.0.
Postprandial levels of sesamin in plasma differed considerably between rats [ 12] and humans [ 11], suggesting a different metabolic pathway depending on species.
We see that the fitness conferred by the metabolic pathway depends strongly on the enzyme production rate constant pEA, except if the nutrient level is always kept within a limited range.
Related(18)
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