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However, there are constraints leading to less obvious metabolic changes, involving a complex global rearrangement of the cell's metabolism.
A particular advantage of metabolomics is that it represents a top-down tactic in that all of the molecules detected are interrogated, providing a global picture of dynamic metabolic changes involving key markers and pathways those were not already associated with carcinogenesis.
Cold acclimation in D. melanogaster is also known to be associated with significant metabolic changes involving sugars (sucrose, fructose, and trehalose), polyamines and a few metabolic intermediates [ 16].
Hypoxia leads to disruption of microenvironmental homeostasis in tumours, where metabolic changes, involving diffusion gradients of oxygen and glucose, develop at microregional level [ 5].
This method enables an effective and high-throughput coverage of the metabolic changes involving the sphingolipidome during physiological or pathological states.
We found that AMI caused comprehensive metabolic changes involving stimulation of glycolysis, suppression of fatty acid oxidation, together with disturbed metabolism of arachidonic acid, linoleate, leukotriene, glycerophospholipid, phosphatidylinositol phosphate, and some amino acids.
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Recently, the metabolic profile of single strain T. b. brucei infections in mice has been studied and a broad range of metabolic changes involved in energy metabolism, symbiotic microbiota-related metabolism, and inflammatory response were found.
The metabolic changes involved a number of pathways of amino acid, steroid and lipid metabolism.
Here we perform untargeted metabolomics to elucidate the metabolic changes involved in miltefosine action.
Simple analysis led to the identification of genetic and metabolic changes involved in TAG and SE accumulation under carbon excess.
Information on the apoptotic activity in tumors and the metabolic changes involved may give valuable insight into the mechanisms underlying cancer progression and treatment response.
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