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CGRP did not induce pontine or thalamic metabolic changes, indicating that it does not modify the neuronal excitability in these central deep brain structures, but rather exerts its effects on the peripheral nervous system and/or the trigeminal ganglion.
Administration of CS during stress period reversed the metabolic changes indicating certain influence on neuro-endocrinological system.
In addition, metabolic changes indicating enhanced integration of FAO with the activity of the TCA cycle have been observed in human subjects after consumption of diets rich in glucoraphanin, the precursor of sulforaphane [ 59].
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SPECT-CT is very sensitive to changes in osteoblastic metabolism; metabolic changes indicate stress in the subchondral bone, which is related to pain [ 10, 12, 15, 16].
Increasing adiponectin concentrations during recovery may reflect resolution of the pro-inflammatory process or a metabolic change indicating a shift towards an anti-inflammatory situation with improved insulin sensitivity.
Lipids, the main energy source of heart cells, also underwent a clear metabolic change, indicated by the increased presence of lipid droplets and induction of medium-chain acyl-CoA dehydrogenase.
Studying gene expression changes in zebrafish (Danio rerio) embryos exposed to 24 hours of hypoxia during development, Ton et al. [ 21] identified transcriptional changes indicating metabolic depression with a switch from aerobic to anaerobic metabolism and energy preservation.
After treatment with valsartan, metabolic changes are indicated by a decrease in insulin resistance and an increase in adiponectin.
The found changes indicate that the metabolic depression observed during the last winter of the lamprey's life cycle is mediated by prolonged reversible mitochondrial dysfunction.
(20) Although the observed changes indicate that rotenone induces a significant metabolic disturbance, absolute CoA measurements represent only a snapshot of this metabolic state.
Metabolic pathway information can aid the interpretation of biological changes indicated by significant differences in metabolite concentration identified in metabonomic studies.
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