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In addition, the effects of rosiglitazone upon inflammatory cytokine transcription, vestibulomotor behavior and spatial memory function were determined at earlier time points (24 h, 1 5 d, 14 20 d post injury, respectively).

Long-term effects on memory function were assessed using the Trace Fear Conditioning test at PND50.

However, effects on memory function were also not detectable after this single dose [ 20].

In such heterochronic parabionts, neurogenesis, synaptic activity and memory function were decreased in young mice when exposed to an old systemic environment.

To determine whether the rhTFAM-induced increases in memory function were associated with changes in BDNF, PSD-95 or synapsin expression, we assayed levels of these proteins and PGC-1-alpha in brains of old mice treated weekly for four weeks with rhTFAM or buffer CTL.

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Lesion and functional neuroimaging studies have found that memory function is lateralized based on material type [ 5] (see [ 6] for review).

This longitudinal functional MRI study examined how material specific memory function is reorganized in patients with TLE after left or right anterior temporal lobe resection and explored the effectiveness of these postoperative memory networks.

In all cases, the amnesia was restricted to autobiographical memory and memory function was restored within 24 hours.

Dr. Chris Gillin, a professor of psychiatry at the University of California in San Diego, called the study intriguing and described it as "the most believable data ever collected that a specific memory function is associated with sleep".

Synapses are destroyed in numerous other neurological diseases, including Alzheimer's, in which the gradual decline of memory function is likely due to loss of synapses in the hippocampus, and major depressive disorder, which is known to involve altered synapse function in the prefrontal cortex.

When memory function is impaired, the impairment is localized.

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