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Exact(6)
Cavey et al. [24] demonstrated that actin patches increase the stability of spot adherens junctions and, consistent with this, we found that E-cadherin and actin co-localised in discrete patches throughout the basolateral membrane of prostate acini.
MCT1 was clearly expressed in the plasma membrane of prostate glands, but not the surrounding stroma.
Cryotherapy markedly redistributed AQP3 protein into the plasma membrane of prostate cancer cells.
Activated c-Src was much more commonly located to the cell membrane of prostate cells compared with the ER-positive breast carcinomas.
The plasma membrane of prostate cancer (PCa) cells provides a primary contact surface with basement membrane, other cancer cells and stroma as well as with immune cells.
At variance with other solid tumours [ 6, 7, 9], we did not find up-regulation of MCT1, MCT4 or CD147 in the plasma membrane of prostate cancer cells, proteins normally involved in the hyper glycolytic-acid resistant phenotype of cancer cells.
Similar(54)
Thus, on the basis of different criteria it appears to be distinct from AR identified on plasma membranes of prostate LNCaP cells.
Most of the UTI in men are complicated, being associated with structural or functional abnormality in urinary tract, requiring frequently prolonged antimicrobial therapy, and needing antimicrobials that can reach high therapeutic concentrations in the prostatic tissues, namely, drugs that are able to cross the electrically charged lipid membrane of the prostate epithelium [ 31].
STAMP2 (Six- trans-membrane protein of prostate 2) has recently been detected in adipose tissue, a key organ in the management of nutrient excesses, and is also expressed in the heart, liver, lung and platelets [ 120].
Several independent experimental techniques confirmed that the newly cloned protein (pmCiC) is a major citrate transporter expressed in the plasma membrane of normal human prostate PNT2-C2 cells and non-malignant prostate tissues.
A recent functional 'neuroscience' approach that we designed to elucidate the pathophysiology of human cancer revealed that membranes of metastatic prostate and breast cancer cells are potentially 'excitable', involving concomitant expression of high levels of VGSC and reduced levels of voltage-gated K+ channel (e.g. Laniado et al, 1997; Fraser et al, 2005).
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Justyna Jupowicz-Kozak
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