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TSPO, formerly known as peripheral benzodiazepine receptor (PBR), is part of a multimeric 'protein complex' associated with the outer mitochondrial membrane of many cells [15].
Gangliosides are sialic acid-containing glycosphingolipids present in the outer leaflet of the plasma membrane of many cell types where they modulate adhesive processes.
Proton-pumping NADH ubiquinone oxidoreductase (respiratory complex I) is a large membrane protein complex of the inner mitochondrial membrane of most eukaryotes and the plasma membrane of many bacteria.
PGE2 appearing at this sub-mucosal level is a product of arachidonic acid metabolism mediated by type-2 cyclooxygenase (COX-2) situated on the membrane of many immune cells.
Many studies have reported that CD44 receptors are over-expressed on the cell membrane of many aggressive tumor cell types [55], such as in breast cancer [56], prostate cancer [57], pancreatic carcinoma [58, 59], ovarian cancer [60], and gastric carcinoma [61].
Folate receptors are overexpressed in the membrane of many human cancer cells such as brain, kidney, breast, lung, retinoblastoma, etc. (Kansara et al. 2008; Saul et al. 2003; Sudimack and Lee 2000) and the expression level of folate receptor in tumors is around 100 300 times higher than in normal tissues (Ross et al. 1994).
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PGE2s appear at this intestinal submucosal level from the metabolism of arachidonic acid mediated by type-2 cyclooxygenases (COX2s) situated in the membranes of many immune cells.
It is noted that folic acid, as an effective target ligand [25, 26], shows high binding affinity with folate receptor, which over-expressed on the membranes of many human malignant cells, but limited on the normal cells.
At 12 13 weeks, HA was expressed strongly along the membranes of many cells in the cortical plate and the layer 1 or marginal zone, but showed weak, spotty expression in a fiber-rich layer adjacent to the cortical plate, called the cortical stratified transitional field-1 (STF-1 or a primitive form of the subplate).
Along with acetylcholine, nicotine is a ligand for nAChRs, which are cholinergic ion channels found in plasma membranes of many different cell types, primarily neurons.
In contrast to mutant cells the vacuolar membranes of many wild-type and reintegrant cells were stained weakly even ten minutes after release of endocytosis (temperature shift from 0 to 30°C after removing excess FM4-64) (Fig. 3A).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com