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By contrast, concern has been raised that neuroleptic medication may increase breast cancer risk due to their prolactin-increasing effect (Schyve et al, 1978) and this has been reported among women with schizophrenia (Nakane and Ohta, 1986; Gulbinat et al, 1992; Lichtermann et al, 2001) and a range of psychiatric disorders (Halbreich et al, 1996; Wang et al, 2002).
Any indication that a medication may increase the risk of serious side effects requires immediate attention.
Recent antidepressant medication may increase risk of incident diabetes.
20, 21, 26 There has been some concern, stemming from early adverse event reports with dapagliflozin, that this class of medication may increase the risk for some cancers, particularly bladder cancer.
One large study linking prescriptions and cancer registration in Denmark indicated that antihypertensive medication may increase risk, but was interpreted as being due to confounding by underlying hypertension (Fryzek et al, 2005).
Bauer et al. [ 35] argued that the individual's experience with tobacco cessation medication may increase the awareness of the benefits of these medications and the utilization of smoking cessation service for future quit attempts especially for those who may have never used either intervention before.
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- However, the simultaneous administration of different medications may increase the likelihood that toxicity will occur.
Although numerous medications may increase likelihood of delirium, the authors were unable to evaluate their impact on the results because of the heterogeneity of pharmacological treatment.
It has also been found that bupropion combined with nicotine replacement medications may increase rate of abstinence relative to bupropion alone [ 36].
Evidence is also emerging that drugs resulting in elevated prolactin (for example, neuroleptic and hormonal medications) may increase breast cancer risk [ 16, 17].
First, diuretic use has been proposed as a risk factor since the use of these medications may increase the volume of urine and worsen UI [ 25] and the association may be specific to those with uninhibited detrusor contractions [ 26].
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