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For some settings, reducing dose may increase adoption of chlorinated water while still providing effective disinfection.
Data are limited regarding CV risks associated with short-term nonsteroidal anti-inflammatory drug use, including injectable formulations, although it has been suggested that even a single dose may increase CV adverse event (AE) risk.
An increased Ad.IL-12 dose may increase the antitumor efficacy but might entail a systemic, toxic effect that would limit the use of Ad.IL-12 alone.
We therefore speculate that administration of MSP68 at the 5 mg/kg dose may increase its protective effect in CLP-induced sepsis.
Our results indicate that iban at a therapeutic dose may increase stress of cortical bone at failure despite the expected fracture-induced osteopaenia.
Since there was no difference between the lower and higher dose groups in the other side-effects induced by tamoxifen, the higher dose may increase the chances of therapeutic success.
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Others raise concerns that high daily doses may increase radiation side effects that can show up years after treatment.
People who receive increased chronic doses may increase their risk of cancer, but no threshold or clear relationship has been definitively shown to exist.
"Because scientific understanding of the radiation effects, particularly at low doses, may increase in the future, it is possible that further investigation may change our understanding of the risks of this radiation accident," the report said.
Thus, once-daily dosing may increase the therapeutic-toxicity ratio by increasing efficacy and decreasing adverse effects [ 57].
Thus, increasing PCB doses may increase intracellular Ca2+ from concentrations that promote dendritic growth to those that cause dendritic retraction.
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