Sentence examples for mediators of peripheral from inspiring English sources

Among these mechanisms, suppression of T cell functions by regulatory T cells (Treg) is crucial and Tregs are now considered as the primary mediators of peripheral tolerance.

Beside their roles in antigen presentation and costimulation of naïve T cells, DCs are also important mediators of peripheral immune tolerance and contribute to the maintenance of immune homeostasis [4].

FoxP3-expressing Tregs are crucial mediators of peripheral tolerance-suppressing autoimmune responses.

Here, we investigated the role of GIRK channels as mediators of peripheral opioid analgesia in primary afferent sensory neurons.

Although these CD4+CD25+ cells make up only a small fraction of the T-lymphocyte population, they are potent inhibitors of immune response [ 7], and are now widely regarded as the primary mediators of peripheral tolerance, able to maintain immune homeostasis, to prevent autoimmunity, and to modulate inflammation induced by pathogens and environmental insults [ 5].

This observation is important because FABP4 is recognised as a biomarker of cardiometabolic risk but it could be considered as mediator of peripheral tissue damage.

The antinociceptive effect of Sc-EtOH is most likely mediated via inhibition of peripheral mediators and central inhibitory mechanisms.

The activity of Sc-EtOH is most likely mediated via the inhibition of peripheral mediators and central inhibitory mechanisms.

Food intake and energy homeostasis are regulated by a complex network of peripheral mediators, such as hormones, neuropeptides, and cytokines.

BoNT-A may therefore be assumed to exert its benefit by repressing the neuro-inflammatory mediators responsible for the maintenance of peripheral and central sensitization [17,18].

However, the variation of peripheral inflammatory mediators and the association with pulmonary histopathologic phenotypes remains a largely uninvestigated research area.