Sentence examples for mediators of mitochondrial from inspiring English sources

Interestingly, all three genes could inhibit the p53-mediated induction of BAX and PIG3, which are known to be key mediators of mitochondrial apoptosis and the DNA damage response pathway, respectively [ 3].

In general, the number and morphology of mitochondria is critically regulated by mediators of mitochondrial fission, such as Drp1 and Fis1, and by mediators of mitochondrial fusion, such as OPA1 and mitofusins (Mfn1 and Mfn2) [27].

Both PGC-1α and NRF1 are important mediators of mitochondrial biogenesis.

In steatotic livers of the PH+I/R group, all mediators of mitochondrial apoptosis tested were lower than in non-steatotic livers.

The expression of these genes (Crb1, Mtfp1, RhoT2, Soc2, and Atp5f1) with a role as regulators and mediators of mitochondrial molecular transport was significantly down-regulated (Fig. 4D).

Perhaps as expected, the antioxidant treatment did not restore autophagy per se, suggesting that ROS are key downstream mediators of mitochondrial dysfunction in the absence of autophagy.

In summary, we provide evidence that mitochondrial dynamics balance is selectively controlled by a transcriptional regulator, unravelling an upstream mediator of mitochondrial fusion.

Mitochondrial uncoupling is regarded as a key mediator of mitochondrial dysfunction in the diabetic heart.

Detection of caspase-3/7 activity was employed since caspase 7 is a critical mediator of mitochondrial events of apoptosis [ 29].

A study has reported that Mfn2 expression (a key mediator of mitochondrial fusion) is reduced in aged persons [92].

In this regard, it is worth noting Drp1, a key mediator of mitochondrial fission, plays a critical role in mitochondrial fragmentation.