Sentence examples for mediators of mechanical from inspiring English sources

Here we show that spatial restriction of the gene expression patterns of PTHLP, BMP2, FGF2, HAS2, CD44, COL2A1 and TNC is responsive to biophysical stimuli in an in vivo context (Figure 7) revealing potential key mediators of mechanical stimulation of joint development that warrant closer analysis.

(E ) The models depicting the mediators of mechanical force-induced Ca2+ influx or ER Ca2+ release.

In particular, calcium ions are the most rapid mediators of mechanical stimuli.

Based on these findings the role of LATS1/2 in these settings is debatable, however, all these studies fully agree that YAP/TAZ function as sensors and mediators of mechanical inputs which are influenced by the cellular architecture and microenvironment.

Nevertheless, recent discoveries of YAP/TAZ as mediators of mechanical stress, GPCR signaling, and Wnt signaling open up the window to understand YAP/TAZ regulation under a complex physiological context in vivo with both physical and chemical properties.

While the involvement of LATS/NDR in the regulation of the actin cytoskeleton is yet to be elucidated in more detail, it is undisputed that YAP/TAZ function as sensors and mediators of mechanical inputs coming from the cellular architecture and microenvironment.

Indeed, we have shown that the protein complex IκB kinase (IKK) is a key mediator of mechanical signals applied to chondrocytes [8], [10].

As well as the gene being sensitive to mechanical stimulation, as an integral part of the ECM and a regulator of joint formation, the gene product may also be an important mediator of mechanical stimuli.

Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain.

In this review we discuss the roles of YAP/TAZ as mediators of responses to mechanical stress, GPCR signaling and the Wnt signaling.

Thus, despite the interactions between established mediators of CSA-AKI and mechanical ventilation have not been formally analyzed, it is rather plausible that mechanical ventilation may act synergistically with established AKI - triggers to further reduce renal function in the perioperative setting.