Sentence examples for mediators of its from inspiring English sources

Thus, these factors were not considered as potential confounders or mediators of its relationship with diabetes.

Furthermore, a correlation was also found between OP-1 and the mediators of its downstream signaling, where OP-1AS treatment inhibited expression of transcription factors, Id proteins 2 to 4 (Table 7), binding protein Gremlin, and MAD genes.

Dysregulation of the Fas receptor and mediators of its signaling pathways have been associated with diseases in humans and mice such as the autoimmune lymphoproliferative syndrome (ALPS) in humans.

Our work indicates that PA-2 possesses chemotherapeutic and chemopreventive efficacy against TNBC in preclinical models, and establishes inhibition of EGFR, acetylation of p53 and induction of oxidative stress as critical mediators of its mechanism of action.

This study was designed to examine the long-term efficacy of UV photography interventions on male outdoor workers, the potential mediators of its impact, and the efficacy of UV photography and skin cancer vs. aging information with this population.

Tumour angiogenesis is implicit in the functions of the endothelium, which not only contributes to the structure of the vessel wall but also promotes further neovascularisation (in the local cancer milieu) by producing angiogenic mediators of its own, such as vascular endothelial growth factor (VEGF) and angiogenin (Folkman 1990; Takahashi et al, 1995; Shimoyama et al, 1999).

Moreover, the identification of HDAC-interacting domain of Bcl11b as a critical mediator of its activity and the finding that BCL11B-mediated apoptosis resistance can be reversed by HDACi may have important implication for therapeutic interventions against BCL11B-positive tumors.

This is the first placebo-controlled study to demonstrate that varenicline reduced cue-provoked cravings, thereby offering another potential mediator of its therapeutic effects.

While vitamin A was a necessary dietary vitamin, vitamin A itself is not the main bioactive mediator of its function.

Expanding this calculation to include KEAP1, a negative regulator of NRF2 and key mediator of its activation by oxidative stress [ 34], explains 37/81 (46%) of the WT 1 day vs. sham SCs.

Since TGF-β may induce CTGF through several pathways, including SMAD, ras/raf/MEK/ERK, Ets-1, JNK, and protein kinase C, CTGF has long been thought to be an important mediator of its fibrotic effects [ 27- 30].