Sentence examples for mediators in many from inspiring English sources

Oxysterols and oxidized lipids are important mediators in many signaling pathways [1], [2].

Nuclear receptors (NRs) are well accepted as critical mediators in many aspects of breast cancer pathogenesis.

In the progress of inflammation, NO is generated by activated inducible iNOS, and participated in the innate response along with other macrophage mediators in many mammal.

Rodent studies demonstrated key roles for inflammatory mediators in many processes critical to memory, including long-term potentiation, synaptic plasticity, and neurogenesis.

Of these activated cells, macrophages play a central role in managing many different immune pathological phenomena such as the over-production of pro-inflammatory cytokines and inflammatory mediators [ 2]. iNOS and COX-2 responsible for the elevated level of NO and prostaglandins, respectively, are well known key pro-inflammatory mediators in many diseases [ 3, 4].

The latter has emerged as a significant lipid mediator in many cellular processes.

Under normal conditions, ROS function as a mediator in many cell signaling pathways.

Melatonin, a neurohormone, plays important roles in adjusting the 'biological clock', and is an important mediator in many normal physiological functions [ 1].

Wnt3a can enhance the expression and activity of phospholipase D1 (PLD1; a cell survival mediator) in many types of cancer cells [ 77] and enhance the expression of PLDs at a transcriptional level, as shown in colorectal cancer HCT116 cells.

For example, a molecule, neuropeptide Y (NPY), is thought to serve as an anti-stress mediator, in many cases having opposite effects to CRF in the brain (Heilig et al. 1994).

The construct has been shown as a moderator or mediator in many different areas of health psychology from addictive behaviors [ 20- 22], physical activity and depression [ 23] to coping with cancer [ 24].