Sentence examples for mediators are implicated from inspiring English sources

Indeed, mast cell mediators are implicated in many different conditions including allergic rhinitis, conjunctivitis, asthma, psoriasis, mastocytosis and the progression of many different cancers.

The pathogenesis of DENV infections is poorly understood although several studies have concluded that soluble factors and mediators are implicated in the development of DHF/DSS.

We found that similar as in a porcine model of retinal detachment [19], inflammatory mediators are implicated in osmotic Müller cell swelling in Dp71-null mice.

Furthermore, a number of inflammatory mediators are implicated in the establishment and progression of arthritis, including proinflammatory cytokines such as tumor necrosis factor alpha (TNFα) and interleukin (IL -6 and IL -6 [ 2, 3].

Chronic basal inflammation: There is increasing evidence that chronic upregulation of pro-inflammatory mediators are implicated in the ageing process and diverse age-related diseases including cardiovascular disease, diabetes and dementia.

Of note, shedding of endothelial glycocalyx induced by pathological mediators is implicated in enhanced accessibility of ICAM-1 to targeted carriers and activated leukocytes.

To discover if any apoptotic mediators were implicated in the enhancement of cell death of HY-PDT-treated tumor cells, selected gene profiling in response to HY-PDT treatment was implemented.

Endothelin-1 (ET-1), a long-acting paracrine mediator, is implicated in cardiovascular diseases but clinical trials with ET-receptor antagonists were not successful in some areas.

This in turn has led to the development of biologic therapies that target cells and mediators that are implicated in inflammatory aspects of the disease.

In mammals, LDs control the synthesis and secretion of inflammatory mediators [20] and are implicated in virus propagation [21].

Reduced availability of NO, important for angiogenesis and maintenance of endothelial integrity, together with increased generation of O2−*, a marker of inflammation and mediator of atherosclerosis, are implicated in decline of vascular function in diabetes [4] [7].