Sentence examples for mediating the local from inspiring English sources

The intracellular signalling pathways mediating the local antihypertrophic effects of ANP/GC-A are unknown.

Increases in local cytokines expression might play a role in mediating the local inflammation and functional alterations of the CB in chronic IH.

Thus, the activation of proinflammatory cytokine pathway may play mechanistic roles in mediating the local inflammation and in contributing to the functional alteration of the CB in chronic IH, leading to the pathogenesis of cardiovascular morbidity in OSA patients.

To gain new insights into the intracellular signalling pathways mediating the local antihypertrophic effects of ANP/GC-A, we compared the influence of ANP on β-adrenergic versus Ang II-dependent (Gs vs. Gαq mediated) modulation of Ca2+i handling in cardiomyocytes and of cardiac hypertrophy in mice.

In this context, the hypoxia-induced osteoblast expression of known mediators of angiogenesis (e.g., VEGF, ANGPTL4, ANGPT1, EDN1) may suggest that subchondral osteoblasts sense and respond to hypoxic microenvironments by mediating the local bone vasculature and may therefore play a central role in the neovascularization pathology previously reported within the OA osteochondral junction.

This effect, which was produced by a single injection of the inhibitor into muscle immediately prior to inoculation, but not after systemic intravenous injection (not shown), showed that JNK functions in the mouse to mediate the local defense response to P. aeruginosa in injured muscle.

This Treg cell subset might mediate the local and systemic suppression in lung adenocarcinoma patients.

Thus, the upregulated expression of the local proinflammatory cytokine pathways could mediate the local inflammation and functional alteration of the CB in chronic IH associated with OSA conditions.

Collectively, these results suggest that the upregulated expression of proinflammatory cytokine pathways could mediate the local inflammation and functional alteration of the CB under chronic IH conditions.

To identify the possible underlying mechanisms by which IL-22 mediates the local inflammatory response during AIA, local cytokine and chemokine production was determined in the joints of IL-22−/− mice.

The aim of the present study was to answer the question which TLR is probably the key TLR in synovium in arthritis, whether triggering of the key TLR directly affects arthritis severity and how the key TLR in synoviocytes is induced to mediate the local inflammatory response.