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Our observations identify a new role for syndecan-1 in mediating the cellular interactions and fate of positively charged submicrometer amorphous silica particles in the alveolar type II epithelial cell, a target cell for inhaled particles.
These results indicate a decisive role of NMDA receptors in mediating the cellular effects of UCB.
However, the importance of ROS generation in mediating the cellular responses to combined MPA and BEZ or some other hitherto unrecognized effects of the drugs remained uncertain.
The role of autophagy in mediating the cellular response to stress has been examined by interferencing the expression of mammalian orthologues of the ATG gene [10].
As a result, Id-bHLH transcription factor heterodimers cannot bind to DNA, leading to the disruption of the events mediating the cellular differentiation and proliferation of a variety of different cell types.
Microarray analysis of exposed A549 cells identified distinct classes of genes whose expression is altered in the presence of germinating conidia and CF and suggested the involvement of both NFkB and MAPK signaling pathways in mediating the cellular response.
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The MRP1 mediates the cellular efflux of various xenobiotics including heavy metals and mediates cellular resistance to heavy metals.
The major transcription factor, which mediates the cellular response to hypoxia, is hypoxia-inducible factor (HIF).
Gene-specific transcription factors are DNA binding proteins that function at the center of the transcriptional machinery to mediate the cellular phenotype in response to extracellular signals.
These proteins could mediate the cellular uptake of siRNA in vitro, though compared with PTD-DRBD gene silencing was attenuated by endosomal entrapment.
Background: 14-3-3 proteins abundantdand and conserved polypeptides that mediate the cellular effects of basophilic protein kinases through their ability to bind specific peptide motifs phosphorylated on serine or threonine.
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