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However, phosphate also has an indirect effect on PTH, mediated through calcium.
Mp.Cr inhibited high K+-induced contraction at low dose as compared to CCh -induced contractions in trachea, so it has bronchodilator effect possibly mediated through calcium channel blockade.
Suggested mechanisms are varied and in addition to those mediated through calcium and parathyroid hormone, include effects on cytokine release and innate and adaptive immunity [ 16].
In earlier studies, we observed that the spasmolytic effect of medicinal plants is usually mediated through calcium channel blockade [ 20, 21].
The spasmolytic effect was mediated through calcium channel blocking (CCB), while bronchodilator activity through a combination of β-adrenergic and CCB pathways, which may explain the traditional uses of A. spinosus in gut and airways disorders.
While the effect of phosphate on PTH, and in result MS, is partly mediated through calcium, the effect of magnesium on MS is mediated through both PTH and T2DM.
Similar(54)
Our results suggests that the plant's mode of action is possibly mediated through the calcium channels, as high molar KCl induced contractions are usually, though not necessarily, through calcium channels [ 25- 27].
The study suggests that, PAC-1-induced mitochondrial permeabilization is mediated through mitochondrial calcium overload and mitochondrial reactive oxygen species (ROS), assisted by endoplasmic reticulum (ER) oxidoreductin-1 alpha (Ero1 α -dependent calcium release from the ER.
Though neither vit D nor magnesium had significant direct effects on MS, for women they both affected MS indirectly, due to the strong direct effect of PTH on MS. For phosphate, the indirect effect on MS, mediated through serum calcium and PTH, had opposite sign than the direct effect, resulting in the total effect on MS being somewhat attenuated compared to the direct effect only.
Such protective effects are possibly mediated through reduction of calcium overload, the mitochondrial intrinsic apoptotic pathway, and the MAPK signaling pathway.
The increases in intracellular calcium stores, mediated through the mobilization and influx of calcium, are essential for many aspects of proper muscle functioning, including contraction, NMJ function, and differentiation.
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